Next, the expression and intracellular location of the well-acknowledged RPE markers Ezrin, Bestrophin, CRALBP, Na+/K+-ATPase, CL19, and ZO1 was analyzed, and the data demonstrated similar RPE characteristics of PXE-specific RPE as compared to the controls, except for CL19 and Bestrophin (Figure 2(b), third and sixth columns from left). The gene discussed is EZR; the disease is Pseudoxanthoma elasticum.