Next, the expression and intracellular location of the well-acknowledged RPE markers Ezrin, Bestrophin, CRALBP, Na+/K+-ATPase, CL19, and ZO1 was analyzed, and the data demonstrated similar RPE characteristics of PXE-specific RPE as compared to the controls, except for CL19 and Bestrophin (Figure 2(b), third and sixth columns from left). This evidence concerns the gene TJP1 and pseudoxanthoma elasticum (inherited or acquired).