Th1-derived cytokines such as IL-2 and INF-γ and their effects on macrophage polarization may play a role in immune response and granuloma development [5]. Although macrophage polarization simplifies the rather complex cell-cell interactions involved in immune regulation and may limit a more nuanced understanding of immune cytokine crosstalk, it does suggest an explanation for the development of sarcoid-like granulomas following the inhibition of the Th2 pathway. This evidence concerns the gene IL2 and Granuloma.