The Whipple triad can be used as the first step in diagnosis, and this includes symptoms of hypoglycemia, recorded low plasma glucose concentrations, and relief of symptoms after administration of glucose [1,3]. IAS should be differentiated from other causes of hyperinsulinemic hypoglycemia such as insulinoma, hypoglycemia from insulin receptor antibodies, and hypoglycemia from insulin and its analogs [1,3]. This evidence concerns the gene INS and Hypoglycemia.