CZS: Congenital Zika syndrome; DENV: Dengue virus; IgM: Immunoglobulin M; IPTp-SP: Intermittent preventive treatment in pregnancy with sulfadoxine-pyrimethamine; PRNT90: Plaque reduction neutralization test 90; PTD: Preterm delivery; RT-PCR: Reverse transcription polymerase chain reaction; SGA: Small for gestational age; ZIKV: Zika virus. The gene discussed is CD40LG; the disease is Zika virus congenital syndrome.