The multivariate-adjusted hazard ratio (HR) was calculated after accounting for age and gender, as well as other factors including body mass index, smoking status, alcohol consumption, history of cardiovascular disease, hypertriglyceridemia, hypo-HDL cholesterolemia, hyper-LDL cholesterolemia, diabetes, chronic kidney disease, hyperuricemia, alanine aminotransferase, and aspartate aminotransferase. The gene discussed is GPT; the disease is hyperuricemia.