The findings from rodent data are also contradictory, with evidence that either APOE3 (Jones et al., 2021; Pandit et al., 2024) or APOE4 (Johnson et al., 2017; Arbones-Mainar et al., 2008) is associated with greater obesity-induced impairments. The gene discussed is APOE; the disease is obesity due to melanocortin 4 receptor deficiency.