It protects against synaptic impairment and oxidative stress induced by fluoride in SH-SY5Y cells by modulating the ERK1/2/Nrf2/HO-1 pathway [18] and against acute pancreatitis-associated lung injury by inhibiting NLPR3 inflammasome activation via the Nrf2/HO-1 signaling pathway [19]. Here, HMOX1 is linked to acute pancreatitis.