Interestingly, XIST dysregulation was found in infiltrating B cells of rheumatoid arthritis joint tissues, which is a chronic inflammatory condition in the same family as asthma (36), suggesting the potential of XIST in the treatment of chronic inflammation, which indirectly justifies the conclusion of the present study that XIST can be used as a therapeutic target for asthma. Here, XIST is linked to rheumatoid arthritis.