Corresponding epigenomic data using transcriptomics in the plasma showed that the expression of enzymes involved in the glycolysis pathway (HK1, HK2, HK3, PFKM, G3PDH, PGK1, ENO1, PKM, LDHA), fatty acid oxidation pathway (CD36), TCA cycle (SDHC) and glutamine pathway (Glud1) were significantly increased in PAH patients (Table 2). The gene discussed is GLUD1; the disease is pulmonary arterial hypertension.