In our mouse model of RV failure with BMPR2 mutation, an increase in glucose metabolites (pyruvate and lactate) observed in the RV is in concurrence with studies done in PAH patients that showed increased 18F-fluorodeoxyglucose uptake in the right ventricle quantitatively measured by using positron emission tomography (FDG-PET) compared to healthy individuals (42–44). Here, BMPR2 is linked to pulmonary arterial hypertension.