Corresponding epigenomic data using transcriptomics in the plasma showed that the expression of enzymes involved in the glycolysis pathway (HK1, HK2, HK3, PFKM, G3PDH, PGK1, ENO1, PKM, LDHA), fatty acid oxidation pathway (CD36), TCA cycle (SDHC) and glutamine pathway (Glud1) were significantly increased in PAH patients (Table 2). Here, PKM is linked to pulmonary arterial hypertension.