In our animal model of RV failure, HK (1 and 2) as well as glucose transporter (Glu1 and Glut8) gene expression remained unchanged which is in contrast to our previously published (52) gene expression data from human RV biopsies from PAH patients which demonstrated an increase in HK2 and glucose transporter (Glut3). The gene discussed is HK1; the disease is pulmonary arterial hypertension.