CTCG15 consists of fifteen CD8+ T cell marker genes, including PLIN2, MSLN, MYH10, RXFP1, OLFML2A, ST6GALNAC4, WASIR2, MRC1, CA3, SHANK3, C8orf88, IL2RA, ITGA2B, PRUNE2 and SEMA4F. Most of these genes have shown associations with the prognosis of AML or the activity of CD8+ T cells, which is in accordance with our results. The gene discussed is SHANK3; the disease is acute myeloid leukemia.