These fifteen genes involved are PLIN2, MSLN, MYH10, RXFP1, OLFML2A, ST6GALNAC4, WASIR2, MRC1, CA3, SHANK3, C8orf88, IL2RA, ITGA2B, PRUNE2 and SEMA4F. Kaplan–Meier analysis revealed a significant association between high CTCG15 risk scores and reduced OS in the training cohort HOVON, suggesting its ability to effectively predict prognosis for AML patients (Figure 3F). This evidence concerns the gene ITGA2B and acute myeloid leukemia.