SHANK3 and acute myeloid leukemia: These fifteen genes involved are PLIN2, MSLN, MYH10, RXFP1, OLFML2A, ST6GALNAC4, WASIR2, MRC1, CA3, SHANK3, C8orf88, IL2RA, ITGA2B, PRUNE2 and SEMA4F. Kaplan–Meier analysis revealed a significant association between high CTCG15 risk scores and reduced OS in the training cohort HOVON, suggesting its ability to effectively predict prognosis for AML patients (Figure 3F).