SACK1A and neoplasm: demonstrated that the HIF-1α/glycolysis axis plays a role in FAM83A-AS1-mediated LA proliferation and metastasis, and the inhibition of tumor development and suppression of HIF-1α expression and glycolysis-related gene expression are seen in vivo with knockdown of FAM83A-AS1, making it a possible biomarker and treatment target for people with LA (38).