AKT1 and familial pancreatic carcinoma: Meanwhile, LncRNA HIF1a - AS1 facilitates the interaction between y-box binding protein 1 (YB1) and serine/threonine kinase (AKT) by regulating the AKT/YB1/HIF1a pathway, which promotes the phosphorylation of YB1 (pYB1) and enhances glycolysis, thereby contributing to gemcitabine resistance in pancreatic cancer (95, 96).