Notably, immune cells such as IgD+ CD24+ %B cell, CD14 on CD14+ CD16- monocytes, and IgD- CD38br AC exhibited odds ratios (ORs) of 0.932 (95% CI: 0.881-0.986), 0.943 (95% CI: 0.900-0.988), and 0.946 (95% CI: 0.918-0.975), respectively, indicating their protective roles against CRC. Here, CD14 is linked to colorectal carcinoma.