IgD+ CD24+ %B cells, IgD- CD38br AC, and IgD+ CD38br %B cells act as protective factors against CRC, while IgD- CD38dim %lymphocyte, BAFF-R on IgD+ CD24-, BAFF-R on naive-mature B cell, BAFF-R on IgD+, BAFF-R on B cell, and SSC-A on B cell are identified as risk factors. This evidence concerns the gene CD24 and colorectal carcinoma.