Prompted by the above-mentioned findings indicating that IFNα primes neutrophils to acquire a fibrotic role through eNETs and since previous results showed that JAK signaling in fibroblasts is involved in COVID-19 immunofibrosis (13), we tried to diminish the fibrotic transformation of fibroblasts either by dismantling the DNA scaffold of eNETs or by inhibiting JAK signaling in these cells. Here, IFNA1 is linked to COVID-19.