In addition, the ADAM10 can impair the recognition of cancer cells by T or NK cells by shedding the “stress-induced” molecules MICA, MICB, and ULBPs expressed on the cancer cell surface, which are responsible for inducing an immune response against cancer cells upon binding to NKG2D receptors expressed on natural killer (NK) cells and most cytotoxic T lymphocytes (11–14). Here, MICA is linked to cancer.