AFP and liver cancer: Furthermore, we also observed that higher ADAM10 expression was often found in liver cancer patients with the following characteristics: age equal to or less than 65 years (Supplementary Figure 9C), larger tumors (Supplementary Figure 9D), G3 and G4 stage patients (Supplementary Figure 9E), higher AFP levels (Supplementary Figure 9F), microsatellite lesions (Supplementary Figure 9G), TACE sensitivity (Supplementary Figure 9H), and sorafenib resistance (Supplementary Figure 9I).