Cancer cells absorb the nanocomposite through endocytosis and produce ROS inside the cell to enhance loss of mitochondrial membrane potential (Δψm), leading to the release of cytochrome C, displacement of Bcl-2 into the cytosol, and triggering of caspase-3 activation for induction of cancer cell apoptosis (Figure 6) (203). The gene discussed is CYCS; the disease is cancer.