The two genes driving the enrichment of natural killer cell-mediated cytotoxicity (LOC509956 [cathepsin G] and LOC100296778 [killer cell lectin-like receptor subfamily I member 1]), both increased in Treated 2+ cattle when compared to Healthy cattle, are indicated in inflammatory airway diseases such as allergen-induced asthma, COPD, and lung adenocarcinoma, and may serve as prognostic indicators (168–173). This evidence concerns the gene CTSG and chronic obstructive pulmonary disease.