The most evident difference between Neu1-/- and WT mice was that Neu1-/- mice had more eye secretions (Figure 7I, Supplementary Figure S3D), and after 24 hours, when symptoms subsided in WT mice, Neu1-/- mice still showed elevated sepsis scores (Figure 7H, Supplementary Figure S3), suggesting an abnormal innate immune response beyond the macrophage-associated immune response. The gene discussed is NEU1; the disease is Sepsis.