Additionally, research on breast cancer survivors demonstrated that a combined regimen of aerobic and anaerobic exercises effectively ameliorated metabolic disorders, reduced circulating biomarkers related to insulin resistance and inflammatory responses—such as insulin, IGF-1, IL-6, IL-8, and TNF-α—and significantly decreased endothelin levels, which are associated with muscle loss and degeneration. This evidence concerns the gene IGF1 and breast carcinoma.