The enzyme was first isolated in the beginningof the 20th centuryfrom different animal sources, and its biological role in the metabolismof l-Asn was elucidated.2 Itsantitumor activity was discovered around 1950 when its impact on lymphomagrowth regression and mice survival was evaluated.3 Since then, l-asparaginase has been used in differenttypes of cancer treatment, including acute lymphocytic leukemia (ALL),T-cell lymphomas, ovarian cancer, and other solid tumors.4 Here, ASPG is linked to acute lymphoblastic leukemia.