In particular, numerous monogenic neurodegenerative, neuropathic and metabolic diseases manifest with tremor often accompanied by signs of other movement disorders, especially of a dystonic (e.g. ANO3, SGCE), ataxic (e.g. PPPP2R2B, ATX3, TBP) or parkinsonian (e.g. LRRK2, FMR1, ATX3) type. This evidence concerns the gene SGCE and metabolic disease.