To sum up, these findings suggest that the pathogenesis of AD may be related to the dysregulation of such PRGs as CASP1, RIP3, CASP4, CASP8, CASP5, PYCARD, CASP6, RIPK1, CASP7, FADD, TNF, CASP2, AIM2, MAPK3, NLRP3, ADAR, and DNM1L, while the association of CASP10, MEFV, CASP12, NINJ1, DFNA5, NFS1, and IFNG with AD needs to be confirmed by further studies. The gene discussed is CASP1; the disease is Alzheimer disease.