To obtain the differential expression of PRGs between the AD group and the control group, we analyzed the differences and found that CASP1, RIP3, CASP4, CASP8, CASP5, PYCARD, CASP6, RIPK1, CASP10, CASP7, FADD, TNF, MEFV, CASP2, AIM2, CASP12, MAPK3, NINJ1, NLRP3, DFNA5, ADAR, DNM1L, NFS1, and IFNG were differentially expressed in AD. Here, CASP4 is linked to Alzheimer disease.