To obtain the differential expression of PRGs between the AD group and the control group, we analyzed the differences and found that CASP1, RIP3, CASP4, CASP8, CASP5, PYCARD, CASP6, RIPK1, CASP10, CASP7, FADD, TNF, MEFV, CASP2, AIM2, CASP12, MAPK3, NINJ1, NLRP3, DFNA5, ADAR, DNM1L, NFS1, and IFNG were differentially expressed in AD. The gene discussed is GSDME; the disease is Alzheimer disease.