TNF and Alzheimer disease: The expression level of CASP1, RIPK3, CASP4, CASP8, CASP5, PYCARD, CASP6, RIPK1, CASP10, CASP7, FADD, TNF, MEFV, CASP2, AIM2, CASP12, MAPK3, and NINJ1 were upregulated, while NLRP3, DFNA5, ADAR, DNM1L, NFS1, and IFNG were downregulated in AD patients (Figure 2B, Table 2).