Sevoflurane directly activates caspase‐1 through AIM2‐2 activation, which leads to neuronal necrosis and apoptosis,38 GSK3β knockdown also restores insulin signal transduction, AMPK and MAPK3 pathways to alleviate AD by re‐establishing the expression of candidate genes linked to these pathways, such as IR, Glut1\3, Prkaa1\2, Mapk3, BDNF.39 The gene discussed is INS; the disease is Alzheimer disease.