Trim5α(136Q) (OR = 3.3 [CI, 95%; 2.74–3.85]), SDF1-3ʹA (OR = 2.2 [CI, 95%; 1.52–2.87]) and CCR5p-59029A (OR = 2.6 [CI, 95%; 1.98–3.22]) may be strongly associated with resistance to HIV infection. Here, CXCL12 is linked to HIV infectious disease.