Thereafter, NIHSS scores, hematoma volume, intraventricular extension of hematoma, and blood glucose levels were incorporated into the multivariate linear regression model, and admission serum IRAK3 levels had independent correlation with NIHSS scores (beta, 6.681; 95% confidence interval, 2.288–11.075; VIF, 2.741; P = 0.003) and hematoma volume (beta, 5.294; 95% confidence interval, 1.974–8.615; VIF, 2.786; P = 0.002). The gene discussed is IRAK3; the disease is hematoma.