IRAK3 and Sepsis: Therefore, it is better that a large number of controls could be enrolled and inclusion of numerous potential confounding factors could be implemented in the future; (5) systemic infection, including sepsis, could influence circulation levels of IRAK3 (22), and nevertheless, this potential confounding parameter was uninvestigated in these patients with ICH, hinting that a further study with incorporation of systemic infection as a recordable variable may be preferred in future studies.