Using a binary logistic regression model that incorporated all these significant variables, NIHSS scores (odds ratio, 1.308; 95% confidence interval, 1.121–1.526; P = 0.001), hematoma volume (odds ratio, 1.076; 95% confidence interval, 1.019–1.136; P = 0.009), and admission serum IRAK3 levels > 99.8 ng/ml (odds ratio, 3.018; 95% confidence interval, 1.261–7.226; P = 0.013) independently predicted poor prognosis at 6 months poststroke. The gene discussed is IRAK3; the disease is hematoma.