In the context of PC, glycan structures such as sialylated and fucosylated Lewis blood group antigens, including Sialyl Lewis a (SLea) and Sialyl Lewis x (SLex), and short O-glycans like the Tn and Sialyl-Tn (STn) antigens, are known to be upregulated and have been associated with increased invasion and metastasis (8–13). This evidence concerns the gene EEF1A2 and pachyonychia congenita.