SLC7A6OS and cancer: IWR-1 had been proved to be a potent inhibitor of WNT/β-catenin pathway in a variety of cancer cells (37, 38).We found that the expression of SOX7 was not changed in A549-Control and H1299-Control cells after treatment with IWR-1 by qRT-PCR and Western blot assays (Supplementary Figures S6A, B).