CTNNB1 and non-small cell lung carcinoma: Furthermore, to verify whether overexpression of SFTPC inhibited EMT process of NSCLC cells through upregulation of SOX7 and then inactivation of WNT/β-catenin pathway, we firstly detected whether overexpression of SFTPC repressed WNT/β-catenin pathway via upregulating SOX7. Our results indicated the knockdown of SOX7 in A549-SFTPC and H1299-SFTPC observably increased mRNA level of CTNNB1(β-catenin) by qRT-PCR (Figure 4A).