FGD5 and breast cancer: For instance, the lncRNA FYVE RhoGEF and PH Domain containing 5 antisense RNA 1 (FGD5-AS1) promotes the radioresistance of breast cancer cells in an FGD5-independent manner, by sponging miR-497-5p, which in turn results in the upregulation of mir-497-5p’s target mRNA, metastasis-associated in colon cancer 1 (MACC1) (Figure 1F) (58).