For instance, through direct binding to the BRCA1 (breast cancer early onset 1, the first breast cancer gene that was ever discovered) promoter and forming a tertiary structure, cisplatin-sensitivity-associated lncRNA (CISAL) sequesters the BRCA1-activating transcription factor GABPA away from downstream regulatory regions (Figure 1C) (49). The gene discussed is BRCA1; the disease is breast carcinoma.