Breast cancer literature already demonstrates the prevalence of sense/antisense gene pair regulation by lncRNAs in mRNA/lncRNA pairs, such as PDCD4/lncRNA PDCD4-AS1 (68), ZNRD1/lncRNA ZNRD1-AS1 (69), HMMR/lncRNA HMMR-AS1 (70), HYOU1/lncRNA HYOU1-AS (71), and HIF-1α/lncRNA HIF-1α-AS (72). The gene discussed is PDCD4; the disease is breast cancer.