An expansion of Il-10+ B cell populations have been noted in patients with autoimmune conditions such as arthritis, multiple sclerosis (MS), Systemic lupus erythematosus (SLE) [51, 52], cancers (e.g. breast cancer, gastric cancer (GC)) [10, 53, 54], and infections (e.g. lymphocytic choriomeningitis virus, and vaccinia virus) [55]. This evidence concerns the gene IL10 and Autoimmunity.