However, many other IL-10+ Breg populations can be stimulated to produce IL-10 under different conditions, for example CD24hiCD38hi Bregs [8] CD24hiCD27+ [61], CD1dhiCD5+ IL-10+ B cells in the spleen of mice and humans, CD19+CD24hiCD27int IL-10+ plasmablasts [62, 63] in autoimmune conditions, and CD25hiCD71hiCD73loIgG4+ IL-10+ B cells during allergic reactions. Here, IL10 is linked to allergic disease.