Additionally, in postmortem AD patient brains and Tau mice models, the euchromatic mark H3K4me3 was significantly increased leading to the upregulation of genes commonly implicated in neurodegeneration such as Sgk1 (serum and glucocorticoid-regulated kinase 1) which is involved in memory formation and neuronal plasticity (Cao et al., 2020; Lang et al., 2010). This evidence concerns the gene MAPT and Alzheimer disease.