For instance, genome-wide hyperacetylation of H3K27 coupled to a decrease in class III HDAC, SIRT1, activity and increased histone acetyltransferase, p300, activity were revealed within the PRKN gene in PD brains (Toker et al., 2021; Milazzo et al., 2020). The gene discussed is EP300; the disease is Parkinson disease.