CCL2 and Alzheimer disease: Comparison of the production levels of pro and anti-inflammatory cytokines in serum showed a significant increase in the expression of the proinflammatory cytokines: IL-1a, IL-17A, IL-12p40, TNF-b, MCP-1, IL-2, and IL-12p70, and the anti-inflammatory cytokines: IL-10, IL-13, and depletion of sCD40Lin AD patients (see Figure 3(a)).