Here, we found that the FDA-approved drug Disulfiram (DSF), which has been used for more than 60 years for the treatment of alcoholism (Wright and Moore, 1990; Suh et al., 2006; Burnette et al., 2022), protects cells from DT, C2 toxin and anthrax lethal toxin (LT). Here, LTA is linked to alcohol drinking.