Indeed, following trauma or disease such as acute ischemia and stroke, brain and spinal cord injuries, and demyelinating diseases such as MS, GPR17 expression is upregulated in neurons, microglia/macrophages, and most importantly in the context of de- and remyelination, in oligodendrocyte precursors (Ciana et al., 2006; Fumagalli et al., 2017; Lecca et al., 2020; Zhao B et al., 2018; Chen et al., 2009). This evidence concerns the gene GPR17 and myeloid sarcoma.