As an intron variant close downstream to the nearest splice site (64 bases), the presence of this polymorphism could have an impact on the splicing process and, therefore, on the correct protein synthesis that could alter the levels of IL1β. This alteration could potentially affect the efficacy of Tocilizumab since IL1β levels have been shown to predict the response to Tocilizumab in rheumatoid arthritis patients (Okano et al., 2016). The gene discussed is IL1B; the disease is rheumatoid arthritis.