Notably, NAFLD progression is often associated with deregulated expression/function of key ferroptosis regulators, such as downregulation of Nrf2, GPX4, and SLC7A11, increased m6A methylation of SLC7A11, and hyperoxidization of peroxiredoxin 3 (PRDX3) 11, 98, 148, which collectively promote hepatocyte ferroptosis. This evidence concerns the gene PRDX3 and metabolic dysfunction-associated steatotic liver disease.