Additionally, NADPH is able to enhance the activity of the E3 ligase, membrane-associated ring-CH-type finger 6 (MARCHF6), which subsequently degrades of key ferroptosis inducers coenzyme A synthase long-chain family member 4 (ACSL4) and p53, and increases anti-ferroptosis proteins, including Nrf2, GPX4 and SLC7A11, thereby attenuating ferroptosis in cancer cells 49. Here, MARCHF6 is linked to cancer.