Interestingly, interferon-γ (IFN-γ) released by CD8+ T cells are able to downregulate the expression of two subunits of system Xc-, SLC7A11 and SLC3A2, while enhance ACSL4 expression in tumor cells, collectively promoting lipid peroxidation and ferroptosis 128, 129. The gene discussed is SLC7A11; the disease is neoplasm.