In pancreatic ductal adenocarcinoma cells under high glucose conditions, SLC2A1-dependent glucose uptake and pyruvate oxidation-dependent fatty acid synthesis facilitate system Xc- inhibitor-induced ferroptosis, while pyruvate dehydrogenase kinase 4 (PDK4), a suppressor of the conversion of pyruvate into acetyl-CoA that is downregulated by SLC2A1, can repress pyruvate oxidation, and thus resist ferroptosis 39. The gene discussed is PDK4; the disease is pancreatic ductal adenocarcinoma.