The highest level of NT-proBNP and Gal-3 was registered in the group of patients with three-vessel disease, and in the group of patients who experienced MACE, confirming the thesis that both biomarkers play an important role in the pathophysiological process of plaque destabilization, Gal-3 as a reflection of the active inflammation in the process of atherosclerosis, and NT-proBNP as a result of hemodynamic changes due to ventricular dysfunction and stress. This evidence concerns the gene LGALS3 and atherosclerosis.