The bubble plot showed that the genes of the antigen processing and presentation (HLA-A, B, C and E) were significantly expressed in the HPV− group (Fig. 5E) and the genes of chemical carcinogenesis-DNA adducts (GSTM3 and 2, EPHX1) were significantly expressed in the HPV+ group (Fig. 5F), indicating that tumor immune activation may accelerate the depletion of myofibroblasts in the patients in the HPV− group. This evidence concerns the gene GSTM3 and neoplasm.