BRCA1 and breast cancer: Breast Cancer (BC) is the second leading cause of cancer-related death among women nationwide.1 Evidence-based guidelines recommend tailored approaches for early detection, based on individual risk.2–6 Women at elevated risk for BC (>20% lifetime risk), based on validated screening tools (e.g. Tyrer-Cuzick), benefit from more aggressive screening to promote early detection of BC.2,3 Risk factors include family history, genetic mutations (e.g., BRCA1/2), hormonal therapies, body mass index, and breast density.