INS and type 2 diabetes mellitus: We will study T2DM patients before and after 6 weeks of high-resistance IMST to test the hypotheses that (1) fasting plasma glucose will decrease, and insulin sensitivity will improve, (2) resting systolic BP will decrease, and (3) high-resistance IMST will improve EDD resulting in clinically-meaningful improvements (i.e., >1% unit change) (29).