Accordingly, we outline a plan to interrogate the effects of 6 weeks of high-resistance IMST on glycemia (fasting plasma glucose), insulin sensitivity/resistance (fasting serum insulin and Homeostasis Model Assessment [HOMA-IR; ratio of fasting insulin/glucose]), resting BP, and NO-mediated EDD in T2DM patients. The gene discussed is INS; the disease is type 2 diabetes mellitus.