For gout, gene-predicted serum iron and TSAT exhibited a positive correlation with the risk (OR [95% CI], 1.3357 [1.0915-1.6345] and 1.2316 [1.0666-1.4221], respectively), whereas transferrin showed a negative correlation (OR [95% CI], 0.8563 [0.7802-0.9399]). The gene discussed is TF; the disease is gout.