The positive correlation between SC abdominal adipose AR and AP-1 protein expression in both study groups combined links AR activation with AP-1 activity, perhaps through Yes-associated protein/transcriptional coactivator with PDZ-binding motif (TAZ)-SV40 transcriptional enhancer factor domain transcriptional complex, as seen in prostate cancer cell lines [45-48]. This evidence concerns the gene AR and Familial prostate cancer.