Therefore, the primary hypothesis of the present paper is that SC abdominal adipose AKR1C3 protein expression is increased in normal-weight women with PCOS compared to age- and BMI-matched normoandrogenic ovulatory women (controls) and is related to SC abdominal adipose AP-1 and/or androgen receptor (AR) protein expression in predicting fat mass accretion. The gene discussed is JUN; the disease is polycystic ovary syndrome.