Normal SC abdominal adipose AKR1C3 protein expression in our normal-weight PCOS women complements previous reports of enhanced SC abdominal adipose AKR1C3 mRNA expression and activity in overweight PCOS women, implicating hyperinsulinemia from adiposity-dependent insulin resistance with SC adipose AKR1C3 activity in some, but not all, studies [7, 29]. The gene discussed is AKR1C3; the disease is Insulin resistance.