INS and polycystic ovary syndrome: If so, given cortisol as an insulin antagonist, diminished cortisol activity relative to androgen excess in normal-weight PCOS women could favor glucose uptake in target tissues, together with reduced breakdown of muscle proteins and TGs, to simultaneously promote energy use in combination with lipid storage and muscle strength in the presence of increased intra-abdominal fat mass [8, 14, 26, 38].