AKR1C3 and polycystic ovary syndrome: In PCOS women, SC abdominal adipose AKR1C3 protein expression positively correlated with total body (R = +0.57, P = .017), android (R = +0.51, P = .037), and gynoid (R = +0.66, P = .004) fat masses but did not predict the android to gynoid fat mass ratio (P = .362) (Fig. 2A-2C, Table 2).