In contrast, a negative correlation of SC abdominal adipose AKR1C3 and AP-1 protein expression in PCOS women differed from that of controls, perhaps linking AP-1 or TAZ with the glucocorticoid receptor [53, 54] and AR/AP-1 transcriptional interference [55-59]. The gene discussed is NR3C1; the disease is polycystic ovary syndrome.