AKR1C3 and polycystic ovary syndrome: Nevertheless, in normal-weight PCOS women, AKR1C3 overexpression accompanying exaggerated lipid accumulation in SC abdominal stem cells during adipocyte development in vitro [9-12] coincides with altered chromatin accessibility of activator protein-1 (AP-1) as a transcriptional regulator of cellular proliferation, differentiation, apoptosis, and inflammation [13].