CALR and autoimmune disease: Of note, his anti-Ro/SS-A and anti-La/SS-B antibodies were negative, two antibodies that are usually correlated with DI-SCLE; however, his positive anti-histone antibodies remain a serologic pertinent positive toward the diagnosis.3 It is important to mention the patient was not autoimmune disease naïve which could have possibly played a role in his presentation.