In the islets of Stage 1 T1D cases, our data point to a reduction in markers of the UPR with several major proteins in the ER quality control system being significantly down-regulated (Figure 3B, Supplemental Figure 2), including P4HB, PDIA2, CANX, CALR, and BiP. The gene discussed is P4HB; the disease is type 1 diabetes mellitus.