Given that SMARCA4-mutant lung cancer cells depend on elevated OXPHOS activity for survival15, we next profiled the IACS-10759 and KD025 combination for their effect on mitochondrial respiration and glycolytic capacities by oxygen consumption rate (OCR) and extracellular acidification rate (ECAR) assays by Seahorse metabolic analyzer. The gene discussed is SMARCA4; the disease is lung carcinoma.