Aggregates of alpha-synuclein (αsyn) phosphorylated at serine 129 (PSER129) are the hallmark of synucleinopathies, which for PD/DLB are found predominantly in neurons (Neuronal cytoplasmic inclusions “NCIs”), but for MSA, aggregates are primarily found in oligodendroglia (Glial cytoplasmic inclusions “GCIs”). This evidence concerns the gene SNCA and Lewy body dementia.