Considering allergy molecular diagnostics,11,12 it has shown that IgE sensitization to Phleum pratense often begins pre-clinically—years before the onset of SAR as a weak, mono- or oligo-molecular profile (2–4 molecules), which in many patients evolves rapidly to a strong, poly-molecular sensitization (5–8 molecules) stage.8 This evidence concerns the gene IGHE and allergic disease.