PCSK9 and familial hyperaldosteronism: Among DL, FH is a common hereditary autosomal dominant disorder characterized by high plasma cholesterol levels, with an estimated frequency of 1 in 200.(36) The most common causes of FH are pathogenic variants of the LDL receptor (LDLR) gene, as well as deleterious mutations in the apolipoprotein B (APOB) gene decreasing the binding of LDL to the LDLR and gain-of-function mutations in the gene for proprotein convertase subtilisin/kexin 9 (PCSK9) resulting in the increased destruction of LDLR.