It has been reported that the enrichment of PUFAs is induced by the suppression of FASN expression.16 Meanwhile, ferroptosis has been linked to drug resistance in numerous cancers.17,18 ADM, a drug used in the first-line chemotherapy regimen for DLBCL, is the main cause of drug resistance in DLBCL patients.19 Therefore, we used ADM to examine the impact of FASN-mediated ferroptosis on DLBCL resistance. This evidence concerns the gene FASN and cancer.