We calculated sensitivities, specificities, and positive and negative predictive values of hs‐cTnT and hs‐cTnI for identification of cardiac involvement using a comprehensive definition that included diastolic left ventricular and right ventricular function, strain analysis using two‐dimensional transthoracic echocardiogram and magnetic resonance imaging, myocardial biopsies, and consideration of a variety of triggers for cardiac injury, including arrhythmias, conduction disorders, and hypoxemia due to respiratory failure. The gene discussed is TNNT2; the disease is cardiac arrhythmia.