For example, insulin can effectively trigger the expression of FOXC2 protein during the differentiation of adipose tissue-derived mesenchymal stem cells, which may be achieved by regulating the activity of the FOXC2-Pro-512T promoter.14 Insulin enhances prostate cancer cells to migrate and invade by up-regulating the expression of FOXC2.15 Thus, we speculated that insulin can influence FOXC2 expression in liver cancer cells, which will lead to a promising direction in exploiting the treatment for liver cancer. This evidence concerns the gene INS and liver cancer.