INS and cancer: Functioning as a high-fat and low-carbohydrate dietary regimen, the ketogenic diet (KD) has been observed to mitigate glucose metabolism while augmenting lipid metabolism, thereby exerting a disruptive influence on the Warburg effect.1 Originally utilized to treat intractable epilepsy, KD has recently grown into an underlying metabolic therapy for cancer by converting fatty acids to ketone bodies in a bid to cut down insulin secretion and switch to fat oxidation as fuel.3 Accumulating studies prove that KD might be an effective anti-cancer treatment.