INS and cancer: It is the only glucose-lowering hormone in the body, so it promotes the synthesis of protein, fat, and glycogen.24 Recent studies have revealed that insulin features in the survival and growth of cancer cells.25 Cao et al26 ascertained the extracellular vesicles secreted by breast cancer cells hinder insulin secretion via miR-122, thereby impairing systemic glucose homeostasis and promoting tumor growth.