MMP9 and neoplasm: For example, within a murine model of colon cancer, KD induces anti-tumor properties by triggering oxidative stress, suppressing MMP-9 expression, and rebalancing the M1/M2 tumor-associated macrophage phenotype.6 In the BALB/c-nu mouse neuroblastoma xenograft model established by the human neuroblastoma cell line (SH-SY5Y), KD may hinder tumor growth by regulating cell autophagy.7 Additionally, some studies have discussed the influence of KD on liver cancer.