A previous study demonstrated that fibroblasts in fibrotic lesions of cardiac fibrosis arise from EndMT using the Tie1‐Cre endothelial lineage reporter mice.[36] Similarly, EndMT also produces myofibroblasts during renal fibrosis.[37] Recent studies have found that EndMT‐transformed cells possess stem cell phenotypes, such as MSCs, which demonstrate that they can differentiate into chondrocytes, osteoblasts, adipocytes, and other cell types.[32, 38] This phenomenon provides a new perspective for tissue repair and regeneration. The gene discussed is TIE1; the disease is renal fibrosis.