For instance, pathogenic BLM variant carriers have lower tolerance to asbestos, leading to increased incidence of mesothelioma, and BLM loss is associated with higher frequency of intestinal tumors in ApcMin mice (Bononi et al. 2020; Cunniff, Bassetti, and Ellis 2017; Goss et al. 2002; Hickson 2003). This evidence concerns the gene BLM and intestinal neoplasm.